Nano Biomedicine
ORIGINAL ARTICLE

Estimation of Controlled Drug-release Behavior of Nano-porous Silica Micro Particles and Their Biocompatibility

Eri SEITOKU1, 2, Yuko ERA1, 3, Ko NAKANISHI4, Yosuke BANDO1, 4, Shinichi KAKUDA2, Koichi NAKAMURA5, Teruo KUSAKA3, Shigeaki ABE3, Mariko NAKAMURA6, Yasutaka YAWAKA5, Junichiro IIDA4, Yasuhiro YOSHIDA3, and Hidehiko SANO2

 1Graduate School of Dental Medicine, 2Department of Restorative Densistry, Fucalty of Dental Medicine,
3Department of Biomaterials and Bioengineering, Fucalty of Dental Medicine,
4Department of Orthodontics, Fucalty of Dental Medicine,
5Department of Dentistry for Children and Disabled Person, Fucalty of Dental Medicine,
Hokkaido University, Sapporo, Japan
6School of Health Science, Kyushu University of Health and Welfare, Nobeoka, Japan Japan
Nano Biomed 2017; 9(2): 112-116, (Dec 30, Nano Biomedicine)
Synopsis
In this study, we investigated the controlled release behavior of a model drug from nano-porous silica microparticles (NPSM) contained in dental glass ionomer cement (GIC). NPSM released model drug molecules gradually in water for 2 weeks when they were contained in GIC. In contrast, GIC-only specimens released the molecule rapidly. To estimate the cytocompatibility of NPSM, osteoblastic cells were exposed to particles with various concentrations. At a concentration of 30 ppm, cell viability remained identical to that without exposure. In addition, mixing the particles did not affect their mechanical properties. These results suggest that NPSM can be used as a sustainable drug-release dental material.

Key words: : nano-porous silica, controlled drug release, glass ionomer cement

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