Nano Biomedicine

Charge and Controlled Release of Epigallocatechin Gallate by Glass Ionomer Cement Containing Nanoporous Silica Particles

Koichi NAKAMURA1, Ko NAKANISHI2, Yosuke BANDO3, Akira HASEBE4, Atsushi HYONO5, Shigeaki ABE6,
Ken-ichiro SHIBATA4, Yasuhiro YOSHIDA6, Junichiro IIDA2, and Yasutaka YAWAKA1

1Department of Dentistry for Children and Disabled Person,
2Department of Orthodontics, Fucalty of Dental Medicine,
3Department of Orthodontics, Graduate School of Dental Medicine,
4Department of Oral Molecular Microbiology, Fucalty of Dental Medicine,
Hokkaido University, Sapporo, Japan
5Department of Materials Chemistry, National Institute of Technology,
Asahikawa College, Asahikawa, Japan
6Department of Biomaterials and Bioengineering, Fucalty of Dental Medicine,
Hokkaido University, Sapporo, Japan

Nano Biomed 2017;9(1):29-34, (Jun 30, Nano Biomedicine)

In this study, nanoporous silica particles (NPS) were synthesized and their controlled drug-release behavior was investigated. The NPS were mixed with glass ionomer cement (GIC), which is a common dental material. Epigallocatechin gallate (EGCG) was charged into the samples as a model drug. Samples were immersed into distilled water; then, the supernatant was analyzed every day using a UV-visible spectrophotometer to observe EGCG-release behavior. GIC containing NPS can release EGCG for more than one week, whereas specimens without NPS released it for only a few days. This suggests that NPS has an excellent ability for sustained drug-release.

Key words: nanoporous silica particles, epigallo catechin gallate, glass ionomer cement, controlled drug-release behavior

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