Nano Biomedicine

The Combined Effect of an Anti-microtubule Agent TZT-1027 and Radiation on Tumor Angiogenesis

Kazumasa MINAMI1, 2, Yoshinosuke HAMADA1, 3, 4, Naomasa KAWAGUCHI1, Seiji MORI1, Kana NAKATANI2, Kento TSUBOUCHI2, Naoki HAYASHI2, Hirofumi YAMAMOTO1, and Masahiko KOIZUMI2

1Department of Functional Diagnostic Science,
2Department of Medical Physics and Engineering,
3Department of Health Economics and Management,
Osaka University Graduate School of Medicine, Osaka, Japan
4Department of Pediatric Dentistry, Osaka Dental University, Osaka, Japan

Nano Biomed 2016;8(2):83-90, (Dec 30, Nano Biomedicine)

Tumor vasculature has a key role in supplying the oxygen and nutrients. Angiogenesis is necessary for tumor growth, survival, and metastasis, therefore, the suppression of tumor angiogenesis is one of the strategies to suppress the tumor growth. TZT-1027, an anti-microtubule agent, has not only cytotoxicity against cancer cells but also inhibitory effects against tumor vasculature. We estimated the effect of combination of TZT-1027 and X-ray on tumor angiogenesis. Human endothelial cells (HUVEC and ECV304 cell line) were irradiated by 4MV X-ray. The invasive, migration and tube forming capabilities of human endothelial cells were significantly suppressed by TZT-1027 with pre-irradiation. However, the cells administrated regent after irradiation did not inhibit the capabili-ties significantly. In this study, we found that combination with TZT-1027 and irradiation exhibited synergistic effects of anti-angiogenesis. These results suggest the possibility that TZT-1027 in the combination with irradiation is one of strategy against cancer treatments.

Key words: X-ray, angiogenesis, migration, invasion, TZT-1027

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