Nano Biomedicine
ORIGINAL ARTICLE

Simple Size-controlled Preparation of Micro-/nano-sized Fullerene C60 Particles using Different Chain-length Diaminoalkane Compounds

 Mami MUTOH1, Shigeaki ABE1, Katsutoshi NAKAYAMA2, Saori YOSHIZAWA1, Mariko NAKAMURA3, Teruo KUSAKA1, Yasuhiro YOSHIDA1, Junichiro IIDA1, and Tomoya TAKADA4
1Graduate School of Dental Medicine, 2Division of Materials Chemistry,
Graduate School of Engineering, Hokkaido University, Sapporo, Japan
3School of Health Science, Kyushu University of Health and Welfare, Nobeoka, Japan
4Department of Applied Chemistry and Bioscience,
Chitose Institute of Science and Technology, Chitose, Japan
Nano Biomed 2015;7(2): 87-92, (Dec 30, Nano Biomedicine)
Synopsis
In this study, we demonstrated a simple preparation of size-controlled fullerene C60 micro-/nano- particles. The fullerene particles were prepared through the reaction of fullerene C60 with a diaminoalkane. The resultant particles were spherical and their size depended on the alkyl chain length of the diaminoalkane compounds. In addition, we successfully modified the hydrophilic surface of the fullerene nanoparticles using succinic anhydrite. The obtained hydrophilic particles are dispersible in water, and the resultant solution is injectable into animals. This surface modification, which involves the introduction of -COOH groups onto the particle surface, may allow the nanoparticle to be tethered to functional moieties such as fluorescence dyes, oligosaccharides, antibodies and drugs. Thus, these simple preparations can widely extend the application of these particles in various fields particularly in biology.

Key words: fullerene nanoparticle, size control, surface modification, water-dispersability

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