Nano Biomedicine
ORIGINAL ARTICLE

Effects on Cell Differentiation and Cell Survival Rate of the Photocurable Resins for Stereolithography

Koichi IMAI1, Mari AKIYAMA1, Isao TAMURA2, Shosuke MORITA3, Tomio ISEKI3, Hiroaki YOSHIDA3, Kazuhiro MATSUMOTO3, Muneyasu SHIDA4, Fumiya OGAWA5, Hirofumi SAWAI6, Tadashi OHKUBO6, Tomohiro HOSHIKA7, and Yoshihiro NISHITANI8
1Department of Biomaterials, 2Department of Oral Anatomy,
3First Department of Oral and Maxillofacial Surgery, 4Department of Endodontics,
5Department of Postgraduate Clinical Training, 6Department of Internal Medicine,
Osaka Dental University, Osaka, Japan
7Department of Operative Dentistry, Okayama University Hospital, Okayama, Japan
8Department of Restrative Dentistry and Endodontology,
Kagoshima University, Kagoshima, Japan

Nano Biomed 2015;7(2): 81-86, (Dec 30, Nano Biomedicine)

Synopsis
Stereolithography, a new molding technique for polymeric materials, should also be applied as a novel method to mold biomaterials into complex curved surfaces in a short period of time using three-dimensional CAD data, which cannot be achieved with conventional cutting methods. However, photocurable resins with potent toxicity have not traditionally been applied directly in vivo as medical materials. For their application to dental molding, photocurable resins with fewer biological risks should be developed.
In the present study, we compared the differentiation rates of ES-D3 cells and the survival rates of Bulb/c 3T3 cells using liquid resins, the unpolymerized products of two epoxy resins and one acrylic photocurable resin, demonstrating less biological damage with the acrylic resins. With these, safer and more reliable photocurable resins will be available for use in both medical and dental fields. In addition, scaffolds for regenerative medicine should be developed using stereolithography.

Key words: stereolithography, rapid prototyping, cell differentiation, cytotoxicity, photocurable resin

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