Nano Biomedicine

Tissue Affinity and Bioabsorption to Fine Calcium Carbonate Particles

Tetsunari NISHIKAWA1, Tomoharu OKAMURA1, Kazuya TOMINAGA1, Masahiro WATO1, Kagami KURIOKA2, Shosuke MORITA2, Koichi IMAI3, Tatsuro MIYAKE4, and Akio TANAKA1
1Department of Oral Pathology, 2First Department of Oral and Maxillofacial Surgery,
3Department of Biomaterials, Osaka Dental University, Osaka, Japan
4Department of Oral Health Sciences, Faculty of Nursing and Health Care,
Baika Women's University, Osaka, Japan

Nano Biomed 2015;7(1): 21-27, (Jun 30)

The scaffold material for the bone formation in the defect must be bioabsorptive. The calcium mineral of the scaffold is used for newly formed bone. In this study, we clarified the tissue affinity and bioabsorption to three kinds of novel fine calcium carbonate particles, LUMINUS, CUBE-18BH and WHISCAL. These particles were added into cell culture, and the mitochondrial activity of culture cell was calculated. These particles were then implanted under the dorsal skin of the rats, and were histopathologically observed.
Five days after addition of the particles, there was no decrease in the mitochondrial activity. The implanted particles had completely disappeared with macrophages, without neutrophils. These kinds of fine calcium carbonate particles were bioabsorbable materials with few inflammatory reactions and were thought to be a useful scaffold for bone formation.

Key words: bioabsorption, lymphocytes, macrophages, calcium particles

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