Nano Biomedicine
ORIGINAL ARTICLE

A Novel Approach for Direct Observation of Biodistribution of Water-soluble Carbon Nanotubes in Mice

 Shigeaki ABE1, Atsushi HYONO2, Fumio WATARI1, Daisuke HAYASHI3, and Tomoya TAKADA3

1Department of Biomedical Materials and Engineering, Graduate School of Dental Medicine,
2Department of Material Science and Engineering, Faculty of Engineering,
Hokkaido University, Sapporo, Japan
3Department of Material Chemistry, Asahikawa National College of Technology, Asahikawa, Japan
Nano Biomedicine 2012;4(2):143-148, (Dec 30)
Synopsis
In this study, we investigated the biodistribution of water-soluble carbon nanotubes (CNTs) after administration through the tail vein of mice. The biodistribution was investigated using an optical and transmission electron measurement. Some of the CNTs remained in the liver and lung even 4 weeks post-injection. We also succeeded in direct observation of CNTs in the excited organs using Raman spectroscopy. In future, this method can allow to observation as a Raman mapping images of CNTs in body.

Key words: carbon nanotubes, biodistribution, Raman spectroscopy, direct observation

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