Nano Biomedicine

Guided Bone Regeneration: Membrane Characteristics and Future Perspectives

Kanako NORITAKE1, 2, Shinji KURODA2, and Shohei KASUGAI2

1Oral Diagnosis and General Dentistry, Dental Hospital,
2Oral Implantology and Regenerative Dental Medicine, Graduate School,
Tokyo Medical and Dental University, Tokyo, Japan.

Nano Biomedicine 2012;4(1):42-46, (Jun 30)

Guided Bone Regeneration (GBR) has been developed for bone recovery at locally compromised sites, facilitating cell proliferation, angiogenesis and osteogenesis, and eliminating fibroblastic interference with membranes. Many studies have been conducted to develop an ideal GBR membrane, and are in pursuit of equipping such a material with certain properties, such as high bio-compatibility, appropriate resorbability, technical convenience and mechanical strength. This search has currently led to the use of expanded polytetrafluoroethylene, synthetic polyesters and collagen. Furthermore, the integration of a biological role, such as the sustained release of chemical agents, is assumed to provide the membrane with a higher bone repair efficacy. Gelatin and hydro-phobized polysaccharide membranes, and their anticipated characteristics, would not only maintain a space for newly formed bone but also act as a reservoir for biologically active molecules to accelerate bone healing.

Key words: guided bone regeneration, membrane, drug delivery system, dental implant

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