Nano Biomedicine

Effects of in Vitro Angiogenesis by Nano or Submicron Diamond Particles

Koichi IMAI1, and Fumio WATARI2

1Department of Biomaterials, Osaka Dental University, Osaka, Japan.
2Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan

Nano Biomedicine 2012;4(1):24-28, (Jun 30)

We have investigated the effects of diamond particles made of the same carbons as fullerene and nanocarbon using an in vitro angiogenesis kit (Toyobo). An undiluted solution had a few effects on the tubule-like structure formation area. However, the effects became smaller at higher dilution rates; no significant difference was observed between the eightfold dilution and control. In vitro angiogenesis has significant effects on tissue regeneration with diamond particles. Dental diamond points are frequently used for cutting and grinding. Thus, a detailed analysis is required of the relationship between diamond particles and angiogenesis.

Key words: diamond particle, angiogenesis, in vitro

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