Synopsis
In this study, we succeeded in preparation and characterization of poly(lactic acid)-coated silicon dioxide particles. Poly(lactic acid) was well-known as a biocompatible polymer. The obtained particles indicated excellent cytocompatibility. For determination of the biodistribution, the obtained particles were administered to mice through the tail vein. After administration, the particles were determined in some organs with energy-dispersed X-ray spectrometer. The polymer-coated silicon dioxide particles were observed in the lung, liver, and spleen. In addition, the particles also detected in the thyroid based on inductively coupled plasma - atomic emission spectroscopy. The distribution behaviors were quite different from non-polymer coated inorganic particles.
Key words: poly(lactic acid), biodistribution, biocompatibility
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