Nano Biomedicine
ORIGINAL ARTICLE
Biodistribution and Biocompatibility of Poly(lactic acid)-coated SiO2 Particle

Shigeaki ABE1, Akiko SASAKI1, Nobuki IWADERA1, Tsukasa AKASAKA1, Motohiro UO2, and Fumio WATARI1

1Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan
2Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan


Nano Biomedicine 2011;3(2): 300-305, (Dec 30)

Synopsis
In this study, we succeeded in preparation and characterization of poly(lactic acid)-coated silicon dioxide particles. Poly(lactic acid) was well-known as a biocompatible polymer. The obtained particles indicated excellent cytocompatibility. For determination of the biodistribution, the obtained particles were administered to mice through the tail vein. After administration, the particles were determined in some organs with energy-dispersed X-ray spectrometer. The polymer-coated silicon dioxide particles were observed in the lung, liver, and spleen. In addition, the particles also detected in the thyroid based on inductively coupled plasma - atomic emission spectroscopy. The distribution behaviors were quite different from non-polymer coated inorganic particles.

Key words: poly(lactic acid), biodistribution, biocompatibility <

"Nano Biomedicine" Homepage(English)

"Nano Biomedicine" Homepage(Japanese)