Nano Biomedicine
ORIGINAL ARTICLE

Establishment of a Treatment Method for Peri-Implantitis Using Bio-Apatite Peening

Hideaki SATO1, Chihiro MOCHIZUKI2, Sora OHBA1,
Yutaka KAMEYAMA1, Shuhei KODAMA1, Yishen XIE3,
Akane OMORI4, and Satoshi KOMASA4


1Department of Mechanical Engineering, Faculty of Science and Engineering,
Tokyo City University, Tokyo, Japan
2BIOAPATITE, INC. Shiga, Japan
3Department of Oral Health Engineering, 4Department of Oral Health Sciences,
Faculty of Health Sciences, Osaka Dental University, Osaka, Japan
Nano Biomed 2026; 18(2): 39-50, (Dec 30, Nano Biomedicine)
Synopsis
Peri-implantitis is characterized by inflammation and progressive bone loss around dental implants. Because bacterial contamination of complex implant surfaces makes re-osseointegration difficult after conventional debridement, surface treatment methods that achieve both decontamination and biofunctionalization are required. This study aimed to investigate a novel approach using bio-apatite particle peening to simultaneously clean and transfer bio-apatite onto pure titanium sur-faces. Bio-apatite particles derived from eggshells were peened onto commercially pure titanium under controlled conditions (pressure: 0.6 MPa, particle mass flow rate: 1 g/s, nozzle distance: 20 mm). The transfer behavior, cleaning efficiency, and biological responses were evaluated using mass measurements, EDS analysis, optical microscopy, and cell culture experiments. The results showed that bio-apatite was successfully peened onto titanium surfaces, and the transfer amount increased with increasing particle peening quantity. Artificial plaque was effectively removed, while bio-apatite transfer occurred simultaneously. EDS analysis confirmed increased Mg content, indicating successful transfer of bio-apatite. Cell experiments revealed enhanced osteoblast adhesion, ALP activity, DNA content, and calcium deposition on bio-apatite-transferred surfaces, especially with higher peening amounts. These findings suggest that bio-apatite particle peening is a promising technique for implant surface modification, enabling simultaneous cleaning and biofunctionali-zation to enhance osteogenic potential.

Key words bio-apatite, peri-implantitis, peening, cleaning, transfer
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DOI: 10.11344/nano.18.39

Sato H, Mochizuki C, Ohba S, Kameyama Y, Kodama S, Xie Y, Omori A, Komasa S. Establishment of a treatment method for peri-Implantitis using Bio-Apatite peening. Nano Biomed 2026; 18: 39-50.