Nano Biomedicine
ORIGINAL ARTICLE

IVNS1ABP Expression Associates with HPV Status and TP53 Mutation in Head and Neck Squamous Cell Carcinoma: A TCGA-based Analysis

Nobuko NIHEI1, Mami ENDOH1, Aiko KUROSAKA2,
Tomoyo JINUSHI1, and Takato NOMOTO1


1Department of Special Needs Dentistry, Nihon University
School of Dentistry at Matsudo, Chiba, Japan
2Oral and Maxillofacial Surgery, The University of Tokyo Hospital, Tokyo, Japan
Nano Biomed 2026; 18(1): 10-20, (June 30, Nano Biomedicine)
Synopsis
Head and neck squamous cell carcinoma (HNSC) is a heterogeneous malignancy in which molecu-lar biomarkers may aid tumor detection and clinically relevant subgrouping, including by human papillomavirus (HPV) status. Influenza virus NS1A binding protein (IVNS1ABP; NS1-BP) encodes a Kelch family protein involved in RNA processing and proteostasis-related pathways and has been implicated by human genetics in early-onset neuropathy syndromes.
We performed an in silico analysis of IVNS1ABP in the TCGA-HNSC cohort using the UALCAN and TIMER3 platforms. IVNS1ABP expression was significantly higher in HNSC tu-mors (n = 520) than in normal tissues (n = 44) and remained elevated across stages and grades. HPV-stratified analyses were definition-dependent: readcount-based stratification showed higher expression in HPV? than HPV+ tumors (p = 9.53~10- 9), whereas p16/ISH-based grouping showed no significant difference. IVNS1ABP expression was higher in TP53-mutant tumors than in TP53-nonmutant tumors (p = 3.43~10- 6) but did not correlate with TP53 mRNA levels. Overall survival was not significant in UALCAN, while TIMER3 stage-adjusted Cox analysis revealed a significant association in HPV+ disease (HR = 1.861, p = 0.015) but not in HPV? disease.
These findings indicate that IVNS1ABP is a tumor- and context-associated expression marker in HNSC, with potential relevance to HPV-stratified risk biology and future diagnostic or transla-tional applications.

Key words IVNS1ABP, TP53, HPV, HNSC, TCGA
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DOI: 10.11344/nano.18.10

Nihei N, Endoh M, Kurosaka A, Jinushi T, Nomoto T. IVNS1ABP expression associates with HPV status and TP53 mutation in head and neck squamous cell carcinoma: A TCGA-based analysis. Nano Biomed 2026; 18: 10-20.