Nano Biomedicine
REVIEW

Hazard of Engineered Nanomaterials to the Central Nervous System: Evidence from Experimental Animal Studies

Alzahraa FERGANY1,2, Aisha FERGANY3, and Gaku ICHIHARA1


1Department of Occupational and Environmental Health, Faculty of Pharmaceutical Sciences,
Tokyo University of Science, Noda, Chiba, Japan
2Laboratory of Genetics and Genetic Engineering in Department of Animal Husbandry and Animal Wealth Development, Faculty of Veterinary Medicine,
Alexandria University, Alexandria, Egypt
3Directorate of Health Affairs, Al Beheira Governorate, Ministry of Health, Damanhour, Egypt

Nano Biomed 2025; 17(2): 41-48, (Dec 30, Nano Biomedicine)
Synopsis
Engineered nanomaterials (ENMs) pose a potential neurotoxic risk, as recent studies indicate that their small size might allow them to cross the protective blood-brain barrier. Animal studies are crucial for assessing this hazard, consistently linking ENM exposure to oxidative stress and chronic neuroinflammation in the brain of mammals. These effects are often associated with the accumulation of harmful proteins and deterioration of cognitive status in neurobehavioral tests. Therefore, evidence from animal models underscores the urgent need for rigorous safety testing or mechanistic studies focusing on the hazardous effect of engineered nanomaterials on the central nervous system.

Key words:Nanomaterial, Animal models, Neurotoxicity, Risk assessment
Full text PDF
DOI: 10.11344/nano.17.41

Fergany A, Fergany A, Ichihara G. Hazard of engineered nanomaterials to the central nervous system: evidence from experimental animal studies. Nano Biomed 2025; 17: 41-48.