Nano Biomedicine
ORIGINAL ARTICLE

Alterations in Antibacterial Properties and Cellular Uptake of Platinum Nanoparticles Mixed with Various Metal Nanoparticles

Mariko NAKAI1, Koichi IMAI2, Minori KOJIMA3, Kiyokazu OZAKI3,
Toshinori OKINAGA4, and Nobutaka OKUSA1

 1Department of Forensic Dentistry, 2Department of Tissue Engineering,
School of Dentistry, Osaka Dental University, Osaka, Japan
3Laboratory of Pathology, Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan
4Department of Microbiology, School of Dentistry, Osaka Dental University, Osaka, Japan
Nano Biomed 2024; 16(2): 102-108, (Dec 30, Nano Biomedicine)
Synopsis
This study investigates the cellular uptake and antibacterial properties of metal nanoparticles (MNPs). MNPs, such as AgNPs, PtNPs, and ZnONPs, are known for their enhanced physico-chemical properties due to their large surface area. AgNPs possess broad-spectrum antibacterial properties, while PtNPs are used for their catalytic and antioxidant properties. ZnONPs are utilized in various industries for their antibacterial and UV absorption properties. The study aimed to im-prove the effects of AgNPs and ZnONPs by mixing them with PtNPs. TEM observations confirmed the uptake of MNPs into lysosomes. Pt-AgNPs significantly reduced biofilm formation, while Pt-ZnONPs did not show sufficient efficacy. Future research should focus on optimizing the mixing ratio and particle size to balance antimicrobial efficacy and safety.

Key words: platinum nanoparticles, antibacterial properties, cellular uptake
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DOI: 10.11344/nano.16.102

Nakai M, Imai K, Kojima M, Ozaki K, Okinaga T, Okusa N. Cellular uptake of platinum nanoparticles mixed with various metal nanoparticles. Nano Biomed 2024; 16(2): 102-108.