Nano Biomedicine
ORIGINAL ARTICLE

Preventing Staining to Hydroxyapatite Disk by Adding γ-cyclodextrin to Beverages Containing Polyphenols

Yoshihiro YOSHIKAWA1, Takeshi HIROSE2,
Susumu TSUDA3, and Takashi IKEO1

 1Department of Biochemistry, Osaka Dental University, Osaka, Japan
2Medical Corporation Ryojyukai, Hirose Dental Clinic, Kyoto, Japan
3Department of Chemistry, Osaka Dental University, Osaka, Japan
Nano Biomed 2024; 16(1): 28-34, (Jun 30, Nano Biomedicine)
Synopsis
In recent years, there has been an increasing demand for milky-white tooth color, prompting research. We devised a new method for preventing tooth staining caused by beverages by using cyclodextrin (CD) as a food additive. CDs are cyclic oligosaccharides consisting of several molecules of glucose linked by α-1,4 bonds. The coloring component of beverages, polyphenols, are incorporated into the cavities of the CDs to form a stable CD-polyphenol complex. In this study, to prevent tooth surface staining caused by various beverages, CDs (specifically α-CD, β-CD, and γ-CD (CDs)) were added to the beverages, which were then applied to hydroxyapatite (HA) discs and the coloration was examined. CDs added to black tea inhibited the tea-induced staining of the HA discs. In particular, β- and γ-CD prevented staining of the HA discs. Furthermore, due to its high water solubility, γ-CD effectively inhibited staining at higher concentrations. γ-CD inhibited staining not only by black tea, but also by various beverages, but the extent of the effect differed among beverages. This study suggests that γ-CD prevents tooth staining because of its ability to incorporate polyphenols.

Key words: Cyclodextrin, Polyphenol, Staining, Beverage

All documents
DOI : "https://doi.org/10.11344/nano.16.28"

J-stage : Yoshikawa Y, Hirose T, Tsuda S, Ikeo T. Preventing staining to hydroxyapatite disk by adding γ-cyclodextrin to beverages containing polyphenols. Nano Biomed 2024; 16: 28-34.