Nano Biomedicine
ORIGINAL ARTICLE

Inhibitory Effects of a Complex of Three Different Phytochemicals on the Growth of Five Types of Streptococcus Species

Tomoharu OKAMURA1, Katsuhiro SUZUKI1, Masumi MORI2, Naoya UEMURA3, Suguru DATEOKA4,
Hajime TABATA5, Harumi ISONO1, Jinhao CUI1, Yukino HISANO1, Takehiro YOSHIKANE1, Chihoko IKEDA1,
Sho AOKI6, Hayato OKA7, Junichi FUJITA7, Naoyuki MATSUMOTO2, and Kazuya TOMINAGA1

 1Department of Oral Pathology, 2Department of Orthodontics,
3Department of Oral Implantology, 4Department of Special Care Dentistry,
5Department of Periodontology, 6Department of Pediatric Dentistry, 7Department of English,
School of Dentistry, Osaka Dental University, Osaka, Japan
Nano Biomed 2023; 15(2):21-26, (Jun 30, Nano Biomedicine)
Synopsis
Bacterial attachment to tooth surfaces via acquired pellicles is important in the mechanism of caries development. Streptococci are the initial colonizers on the tooth surface. Dental plaque maturation occurs when late-established bacteria bind and grow on the outside of the early-established bacte-ria. Phytochemicals are part of the plant defense system, and a variety of antimicrobial components are known to exist. However, the effects of complexes containing multiple phytochemicals on the initial settlement of bacteria in dental plaque are not known.
In this study, we prepared a complex of three Phytochemicals (IP2). Then we investigated the inhibitory effects of a complex of three different phytochemicals on the growth of five types of early-occupying bacteria constituting dental plaque. As a result, there was a large inhibitory effect on the number of all colonies.

Key words: antibacterial test, colony growth inhibitor, early-occupying bacteria, streptococci, phytochemicals

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DOI "https://doi.org/10.11344/nano.15.21"

J-stage Okamura T, Suzuki K, Mori M, Uemura N, Dateoka S, Tabata H, Isono H, Cu J, Hisano Y, Yoshikane T, Ikeda C, Aoki S, Oka H, Fujita J, atsumoto N, Tominaga K. Inhibitory effects of a complex of three different phytochemicals on the growth of five types of streptococcus species. Nano Biomed 2023; 15(1): 21-26.