Nano Biomedicine
ORIGINAL ARTICLE

Antibacterial Activity and Biofilm Dispersion of an Isopropyl Methylphenol-containing Dentifrice

Chisa YOSHIKAWA1, Masanori HASHIMOTO1, Kengo IWASAKI2, and Kazutoshi KAKIMOTO1

 1Faculty of Health Sciences, Osaka Dental University, Osaka, Japan
2Translational Research Institute for Medical Innovation,
Osaka Dental University, Osaka, Japan
Nano Biomed 2023; 15(1):1-6, (Jun 30, Nano Biomedicine)
Synopsis
Recently, novel antibacterial substances have been developed and added to available dentifrices. Isopropyl methylphenol (IPMP) exerts an antibacterial effect on a wide range of bacteria with biosafety, and thus, is a component recently added in the disinfectants of dentifrices. Accordingly, this study aimed to evaluate the antibacterial effect of a commercially-available IPMP-containing toothpaste on Streptococcus mutans. The antibacterial effects of different concentrations (0, 0.1, 1.0, and 10%) of the dentifrice were examined via colony-forming, biofilm formation, and dispersion assays.
The results of this study demonstrated that bacterial colonization was inhibited in culture media containing 10% dentifrice, and biofilm formation was suppressed even at relatively low dentifrice concentrations (0.1 and 1.0%), however, the removal of the biofilm that had already formed was difficult. Hence, the evaluated dentifrice was considered effective for appropriate oral care. However, the ingredients responsible for this effect need to be identified and compared with other commercial products.

Key words: dentifrice, IPMP, S.mutans, biofilm, colony forming



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DOI "https://doi.org/10.11344/nano.15.1"

J-stage Yoshikawa C, Hashimoto M, Iwasaki K, Kakimoto K. Antibacterial activity and biofilm dispersion of an isopropyl methylphenol-containing dentifrice. Nano Biomed 2023; 15(1): 1-6.