Nano Biomedicine
ORIGINAL ARTICLE
Cell Viability by Photo Irradiation with a Medium Containing Both Bis-GMA and Camphorquinone (CQ)
Tsubasa SHIRAI1, Tan CHENG1, Yuzhu SUN1, Yufan WU1, Ye ZHANG1, Tetsuya HIRATA2, Yoshiya HASHIMOTO1, and Koichi IMAI3, 4
1Department of Biomaterials, School of Dentistry, Osaka Dental University, Osaka, Japan
2Div. of Oral Maxilofacial Regeneration, Faculty of Dentistry, Osaka University, Osaka, Japan
3Department of Tissue Engineering, School of Dentistry, Osaka Dental University, Osaka, Japan
4School of Health Sciences, Osaka Dental University, Osaka, Japan
Nano Biomed 2021; 13(1):8-12, (Jun 30, Nano Biomedicine)
Synopsis
Little is known about the influence of the phototoxicity of dental materials. Light-cured composite resin is polymerized by intense light irradiation in the oral cavity, although it is temporary. There has been no report on the biological influence of intense light irradiation on oral cavity tissue. We previously confirmed that camphorquinone (CQ) contained in light-cured composite resin for dental use as a photosensitizer decreased the cell viability in a light-irradiated group compared with that in a non-irradiated group within a concentration range from 0.313 to 2.5 mg/mL using 3T3 cells specified in the OECD phototoxicity guidelines. In this study, we investigated the influence of light irradiation in actual light-cured composite resin mixed with Bis-GMA contained as a base monomer, not the influence of CQ alone, on the influence of light irradiation on cell viability. It was confirmed that similarly to CQ alone, the cell viability decreased in the state mixed with Bis-GMA.
Key words: cell viability, Bis-GMA, camphorquinon, CQ, light-cured composite resin
All documents in this paper (Free)
J-Stage https://www.jstage.jst.go.jp/article/nano/13/1/8_12/_article
DOI https://doi.org/10.11344/nano.13.8
Little is known about the influence of the phototoxicity of dental materials. Light-cured composite resin is polymerized by intense light irradiation in the oral cavity, although it is temporary. There has been no report on the biological influence of intense light irradiation on oral cavity tissue. We previously confirmed that camphorquinone (CQ) contained in light-cured composite resin for dental use as a photosensitizer decreased the cell viability in a light-irradiated group compared with that in a non-irradiated group within a concentration range from 0.313 to 2.5 mg/mL using 3T3 cells specified in the OECD phototoxicity guidelines. In this study, we investigated the influence of light irradiation in actual light-cured composite resin mixed with Bis-GMA contained as a base monomer, not the influence of CQ alone, on the influence of light irradiation on cell viability. It was confirmed that similarly to CQ alone, the cell viability decreased in the state mixed with Bis-GMA.
Key words: cell viability, Bis-GMA, camphorquinon, CQ, light-cured composite resin
All documents in this paper (Free)
J-Stage https://www.jstage.jst.go.jp/article/nano/13/1/8_12/_article
DOI https://doi.org/10.11344/nano.13.8