The field of regenerative medicine has recently made marked advances in stem cell research. Adult stem cells, called somatic or tissue stem cells that can only be differentiated into limited cell types have been generally used for regenerative medicine. However, with the development of iPS cells, tissues and cells of interest will be artificially generated and implanted into patients to repair sites of damage. In the present study, technical objectives for this purpose are summarized.
Furthermore, studies on cell adhesion have demonstrated that the surface morphology of materials influences cell differentiation and proliferation. The influence of intelligent material surface structures and nanomaterials on cell differentiation has been greatly highlighted. The artificial materials and regeneration are being investigated for regenerative medicine in the field of dentistry.
Key words: regenerative medicine, differentiation, iPS cell, serum, four-dimensional culture
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