Nano Biomedicine

The Change of Plasma Potassium Level in Hemodialysis is a Strong Predictor for High Risk Premature Ventricular Contraction

Nanami KIDA1, Shunro AGETA2, Masayuki NAGAHARA1, Yoshinosuke HAMADA1,3,4, Masaaki KAWAGOE1, and Nariaki MATSUURA1

1Department of Health Economics and Management, Osaka University Graduate School of Medicine and Health Science, Osaka, Japan 2Blood Purification Center, Nagahara Hospital, Osaka, Japan 3Department of Molecular Pathology, Osaka University Graduate School of Medicine, Osaka, Japan 4Department of Pediatric Dentistry, Osaka Dental University, Osaka, Japan

Nano Biomed 2019; 11(2): 71-78, (Dec 30, Nano Biomedicine)

Background: The most frequent cause of sudden cardiac death is ventricular arrhythmia which usually precedes premature ventricular contraction (PVC). In this study we examined the incidence of severe PVC by 24 hour electrocardiogram (ECG) in the hemodialysis patients and analyzed the factor associated with severe PVC.
Methods: After the examination of 24-hour ECG, we divided patients to severe PVC groups (Lown classification III-V) and low-risk own. The association of the incidence of PVC, especially severe PVC, with clinical characteristics and biochemical data was analyzed in order to investigate the predictable factor for PVC.
Results: 70 patients (21 females and 49 males) were analyzed in this study. Severe PVC was observed in 6 patients. There was significant difference in age, and serum potassium level change (1.5 VS 1.1mEq/l :p<0.05) between severe PVC and low-risk groups. In logistic regression analysis, serum potassium level change was the only significant predictable factor for the incidence of severe PVC.
Conclusions: Serum potassium level change is significantly associated with development of severe PVC in hemodialysis patients.

Key words: hemodialysis, potassium, premature ventricular contraction, 24 hour electrocardiogram

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