Dental metals have toxic effects on human development, including the high toxicity of the constituent element vanadium of the standard product ASTM F136, i.e.
, the medical titanium material of the Ti-6Al-4V alloy used in dental implants for its mechanical strength due to the use of a large amount of pure Ti. In addition, the corrosion of pure Ti and Ti alloy implants due to fluorides in the oral cavity is a problem. Elution of the constituent element vanadium due to corrosion may have toxic effects on development. Therefore, each element composing Ti-6Al-4V was examined in an in vitro embryotoxicity test by the Embryonic Stem Cell Test (EST) protocol. As a result, only vanadium had a risk of embryotoxicity. In addition, the Ti-6Al-4V alloy was corroded with hydrofluoric acid to examine its effects on the differentiation of mouse-derived ES and iPS cells, and was found to affect the differentiation of both cell types.
Key words: Ti-6Al-4V, corroded, hydrofluoric acid, embryotoxicity, EST
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