Silver nanoclusters (AgNCs) are ultrasmall in size (< 2 nm) and are expected to be an effective an-tibacterial substance to combat oral infective diseases. In the present study, we synthesized AgNCs (Ag~75
) as the main component for esthetic and antibacterial application against the caries pathogen Streptococcus mutans
. The results showed that AgNCs significantly reduced the turbidity and viability of S. mutans
. In addition, the bactericidal effects of AgNCs were confirmed by LIVE/DEAD staining. After AgNC application to human dentin, no discoloration of dentin was observed, as compared to silver diamine fluoride application, and AgNC-treated dentin showed an inhibitory effect on colony formation by S. mutans
. Therefore, AgNCs appear to be beneficial for dental therapy as an antibacterial and/or esthetic substrate.
Key words: antibacterial effect, human dentin, silver nanoclusters (AgNCs), streptococcus mutans
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