Nano Biomedicine

Reproducibility in Testing Method with Stirring for In Vitro Glass-ionomer Cement Research

Shinichi KAKUDA1, Shigeaki ABE2, Pipop SAIKAEW1, 3,
Almas AFM CHOWDHURY1, 4, and Hidehiko SANO1

1Department of Restorative Dentistry, 2Department of Biomaterials and Bioengineering,
Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
3Department of Operative Dentistry and Endodontics, Faculty of Dentistry, Mahidol University, Bangkok, Thailand
4Department of Conservative Dentistry and Endodontics,
Sapporo Dental College and Hospital, Dhaka, Bangladesh

Nano Biomed 2018; 10(2): 48-52, (Dec 30, Nano Biomedicine)

Glass-ionomer cement is primarily used for its ability to prevent caries due to sustained release of fluoride. In recent years, it has been proven as a carrier of various kinds of ions other than fluoride, and attention is paid to its property as a bioactive material. However, the release of ions from the material is not stable, and therefore, the reproducibility of the experiments is poor and variations are common. In this study, we investigated whether the presence or absence of stirring affects the stability and reproducibility of the reactions, aiming to optimize the research conditions for obtain-ing more consistent results. Our results suggest that the values obtained with continuous stirring are significantly more stable than the values obtained from stationary conditions.

Key words: Bioactive glass, Acidity, Buffering, Reproducibility, Glass-ionomer cement

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