Program of the 17^th Annual Meeting

Symposium I

Chair：Kanjiro Miyata (Univ. of Tokyo)

13:30-14:00 S-I-1

mRNA engineering for nano-drug delivery systems and vaccines

Satoshi Uchida
Medical Chemistry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine

14:00-14:30 S-I-2

DNA nanobiotechnology based on structural biomimetics

Jiro Kondou
Faculty of Science and Technology of Sophia University

14:30-14:40 Break
14:40-15:10 S-I-3

Rational design of short DNA strand-based engineering for precise nanobiomaterials

Yoshitsugu Akiyama
Institute of Arts and Sciences, Katsushika Division, Institute of Arts and Sciences, Tokyo University of Science

15:10-15:40 S-I-4

Nucleic acid aptamer therapeutics for blood diseases

Keitaro Yoshimoto
Sciences, Graduate School of Arts and Sciences, The University of Tokyo

15:40-15:50 Break

Symposium II

Chair：Keitaro Yoshimoto (Univ. of Tokyo)

15:50-16:20 S-II-1

Evolution of Precise Polymers that Recognize Peptides

Yu Hoshino
Department of Applied Chemistry, Faculty of Engineering, Kyushu University

16:20-16:50 S-II-2

Design of synthetic polymer nanoparticles for sepsis therapy

Hiroyuki Koide
Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka

16:50-17:00 Excellent Presentation Award Ceremony

17:00-17:05 Closing Remarks

9:00-9:05 Opening Remarks

General Session

General Session I

Chair : Ikuko Matsunaga (Univ. of Tokyo) / Toshiaki Takezawa（NARO）

9:05-9:20 O-I-1

Brain tumor targeting of immune checkpoint inhibitors by detachable antibody PEGylation

Yuki Mochida, Tao Yang, Xueying Liu, Hiroaki Kinoh, Horacio Cabral, Kazunori Kataoka
Kawasaki Institute of Industrial Promotion, Innovation Center of NanoMedicine

9:20-9:35 O-I-2

Polydopamine-mediated surface functionalization of extracellular vesicles

Chenyu Wang and Hirotaka Ejima
Department of Materials Engineering, The University of Tokyo

9:35-9:50 O-I-3

Analysis of protein adsorption and bactericidal ability of the well-controlled cationic polymer brush surfaces

Tsukuru Masuda, Yoichi Watanabe, Madoka Takai
Department of Bioengineering, School of Engineering, The University of Tokyo

9:50-10:05 O-I-4

A promoted redox activity of copper complexes by forming locally concentrated state through installing on the polymer chains toward antibacterial application

Shigehito Osawa¹, Kenichi Kitanishi¹, Maho Kiuchi², Motoyuki Shimonaka^1,2, Hidenori Otsuka^1,2
¹Fac. of Sci.,Tokyo Univ. of Sci. ²Grad. Sch. of Sci., Tokyo Univ. of Sci.

10:05-10:20 O-I-5

Effects of fine powders in hybrid resins for CAD/CAM crowns on rodent cells

Mariko Nakai¹, Koichi Imai², Yoshiya Hashimoto³, Nobutaka Okusa¹
¹Department of Forensic Dentistry, Osaka Dental University, ²Department of Tissue Engineering, Osaka Dental University, ³Department of Biomaterials, Osaka Dental University

10:20-10:35 O-I-6

Construction of AAV delivery systems based on phenylboronic acid-conjugated polymers and polyphenol molecules

Yuto Honda^1,2, Shuhei Nagao^1,2, Hiroaki Kinoh³, Nozomi Matsudaira^1,2, Liu Xueying³, Takahiro Nomoto^1,2, Dirisala Anjaneyulu³, Nobuhiro Nishiyama^1,2
¹Department of Life Science and Technology, School of Life Science and Technology, ²Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology ³Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industrial Promotion

10:35-10:50 O-I-7

Improvement of Immunostimulant Activity of CpG Oligodexynucleotides by Formation of Guanine-Quadruplex Structure

T. YAMAZAKI^1,2, A. TU^1,2, N. LE^1,2, S. PATHAK^1,2, K. TSUKAKOSHI³3, K. IKEBUKURO³
¹Res. Cent. Funct. Mater., NIMS, ²Grad. Sch. Life Sci., Hokkaido Univ., ³Grad. Sch. Tech., Tokyo Univ. Agric. Technol.

10:50-11:00 Break
General Session II

Chair：Koki Kanehira (TOTO Ltd.) / Akira Taniguchi (NIMS)

11:00-11:14 O-II-1

Effect of UV Irradiation on the Surface of Collagen-Derived Cell Scaffold Sheets

Keita HARAGUCHI², Yushi OISHI², Shigehisa AOKI^1,3, Toshiaki TAKEZAWA^1,4, Takayuki NARITA^1,2
¹Vitrigel Collaboration Laboratory between NARO and Saga University, ²Department of Chemistry and Applied Chemistry, Saga University. ³Department of Pathology, Saga University. ⁴Institute of Agrobiological Sciences, National Agriculture and Food Research Organization

11:14-11:28 O-II-2

Bioabsorbable microneedle device for access to blood vessels

Yukihiro Kanda, Hiroaki Takehara, Takanori Ichiki
Department of Materials Engineering, School of Engineering, The University of Tokyo

11:28-11:42 O-II-3

Study of a drug delivery system composed of poly(vinyl alcohol) and D-4-boronophenylalanine for boron neutron capture therapy

Kakeru Konarita^1,2, Takahiro Nomoto^1,2, Minoru Suzuki³, Nobuhiro Nishiyama^1,2
¹Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, ²School of Life Science and Technology, Tokyo Institute of Technology, ³Institute for Integrated Radiation and Nuclear Science, Kyoto University

11:42-11:56 O-II-4

Physical properties and nose-to-brain delivery of nanoparticles composed of PEGPCL block copolymers with different molecular weights of PEG and PCL

Shingo Iioka¹，Takanori Kanazawa¹，Tamaki Yoshida¹，Shunsuke Aoki¹, Takayuki Terukina¹, Kenjiro Azuma², Masatoshi Maeki³, Manabu Tokeshi³, Hiromu Kondo¹
¹ Graduate School of Pharmaceutical Sciences, University of Shizuoka, ²Laboratory of Pharmaceutical Technology, Chiba University, ³Faculty of Engineering, Hokkaido University

11:56-12:10 O-II-5

Temperature-responsive polyion complex structures capable of sustained release of micelles constructed from oligonucleotides

Hiroshi KAMIZAWA¹, Rento OTA¹, Ziwei MA², Teruki NII², Takeshi MORI^2,3, Yoshiki KATAYAMA^2,3,4,5, Akihiro KISHIMURA^2,3,4,6
Grad. Sch. Sys. Life Sci., Kyushu Univ¹, Dept. of Applied Chem., Fac. of Eng., Kyushu Univ.², Ctr. for Molecular Systems, Kyushu Univ³, Ctr. for, Future Chem., Kyushu Univ.⁴, The Ctr. For Adv. Med. Innov., Kyushu Univ.⁵, RIKEN Center for Emergent Matter Science⁶

12:10-12:24 O-II-6

Precisely regulated PEGylation of mRNA for enhanced systemic delivery via polymeric nanoparticles

Kohki Yamada¹, Jongmin Yum¹, Mitsuru Naito¹, Satoshi Uchida², Hyun Jin Kim³, Kanjiro Miyata¹
¹Graduate School of Engineering, The University of Tokyo, Japan, ²Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan, ³College of Engineering, Inha University, Korea.

12:24-12:38 O-II-7

Design of thrombin-binding bivalent aptamers and control of their anticoagulant activity

Kazuki Kubota¹, Masanobu Nagano¹, Asuka Sakata², Keitaro Yoshimoto¹
¹Graduate School of Arts and Sciences, The University of Tokyo, ²Nara Medical University

12:30-13:20 Break
13:20-13:30 General Meeting of the Society of Nano Biomaterals